4-Methylmethcathinone (also known as 4-MMC, M-CAT, drone, meow meow, and mephedrone[1]) is a novel entactogen-stimulant substance of the cathinone class. Mephedrone belongs to a group known as the substituted cathinones, which are derivatives of the active ingredient in the khat plant (Catha edulluis). It is thought to produce its effects by promoting the release of the neurotransmitters serotonin, dopamine, and norepinephrine in the brain.[citation needed]

Mephedrone was first synthesized in 1929, but did not become widely known until it was rediscovered in 2003. In 2007 it was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010 it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom.[citation needed]

Subjective effects include stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is reported to produce a mixture of classic stimulant and entactogenic effects reminiscent of cocaine and MDMA.[1] It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally. It is also sometimes sold as MDMA ("molly").

Limited data exists about the pharmacological properties, metabolism, and toxicity of mephedrone, and it has little history of human use. Preliminary evidence suggests it may possess neurotoxic and cardiotoxic properties.[citation needed] It is highly advised to use harm reduction practices if using this substance.

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